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Subree subramanian rate umn11/9/2022 ![]() ![]() FBXW7 is a key component of the ubiquitin-protease system targeting multiple transcription factors that in turn control multiple oncogenic networks. Subree subramanian rate umn driver#identified two additional key miRNAs, miR-182 and miR-503, which mediate malignant transformation by cooperatively targeting a key colon cancer driver gene, FBXW7. Another recent article, published by Li et al. There is additional evidence that miR-135b also acts as a downstream effector of the EGFR/STAT3 pathway, making this common signaling mediator an attractive anti-cancer therapeutic target. demonstrated that miR-135b promotes colorectal cancer progression, functioning as a downstream effector of the PTEN/PI3K oncogenic pathway. established that miR-215 is the link between the CDX1 transcription factor and its repression of polycomb complex protein BMI, which results in increased colorectal cancer stem cell differentiation, a key step towards tumor formation. The preponderance of results published over the last couple of years clearly seems to indicate that miRNAs are active participants in cancer formation and progression. MicroRNA (miRNA) dysregulation is an established feature of colon cancer progression but it has not been clear whether this dysregulation is driving transformation and progression, or whether other driving events (such as p53 mutations) are incidentally causing changes in miRNA expression. There is both a critical need and opportunity for novel treatment strategies that either halt or prevent the transformation from polyp to cancer. ![]() Despite the increased preventive screening, colorectal cancer remains a deadly disease, with an estimated 136,830 new cases and 50,310 deaths in the United States in 2014. The decreasing mortality rate is largely credited to increased screening with sigmoidoscopy, colonoscopy, and fecal occult blood tests that result in early detection of precancerous polyps or early stage colon cancer. The benign to cancerous transition is a critical intervention stage as tumors diagnosed in subsequent non-localized and malignant stages are exponentially more difficult to treat successfully. The question, “What determines whether a polyp will become cancerous?” was recently declared one of the five central puzzles critical to advancing colon cancer treatment. ![]()
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